Sarcoma Project Web Site Overview

The site is intended to allow interaction with sets of data regarding a set of human cell lines, mostly sarcoma-derived but including some "normal" cell lines. The categories of available data are concentration/response data for a set of approved and investigational cancer drugs, Affymetrix Exon Array data (aggregated by UniGene cluster), and NanoString microRNA expression data.

Lists of the recognized search terms for each data category are available.

Data can be searched by any combination of NSC compound identifier and drug names for concentration/response data, GeneCard (HUGO) gene symbol for Affymetrix Exon Array data, or miRbase microRNA identifier for NanoString data.

Searches can be restricted to a subset of the cell lines or sarcoma panels, which identify subgroups of the cell lines by sarcoma type. There is also a "normal" panel for the expression data. By default, data for all cell lines and panels will be returned. If any cell line and/or panel are selected then only data for those cell lines and panels will be returned. This selection is INCLUSIVE: Data for all cell lines which are in the selected panels will be returned along with data for any selected cell lines which are not in the selected panels.

Search Results

A search result is a single value for a cell line and a data type.

Alternative Data Formats

Data can be accessed in several different formats:

Links to trigger actions on the data

Depending on the data format, various actions can be triggered.

Data download

The underlying data for each format can be downloaded as Excel or CSV files.

Image download

The heat maps, mean graphs, concentration/response curves, AllPlots, and PanelPlots can all be downloaded as .png images.

Images on web pages

On the web pages the concentration/response curves and mean graphs are rendered as Html "canvas" elements which are not accessible to Screen Readers. In addition to the option to download the data, listed above, data tables, and charts (heatMaps, meanGraphs, concentration/response curves) are preceded by an "Alternate Table" link which renders a table intended to be accessible to users of screen readers.

Web Page Layout

There are sets of navigation buttons on the web pages grouped by sections. Navigation buttons are active or disabled depending which data categories were populated during the most-recent search, and in which format the data are being presented.